![]() ![]() A feasible solution could be a small production facility that would use technologies with high yield at low costs of goods to cover the regional needs. The diverse political ambitions among African governments make it difficult to predict and access the market, a prerequisite for competitive production. The global vaccine stakeholders showed less preference in investment for vaccine production establishment in Africa. The common regulatory functionality gap was the quality control laboratories to test vaccine lots before regulatory release. We saw that, governments in Africa, show interest in vaccine production establishments but only with external support for investment. We also developed business plan scenarios including facility costs calculations and a possible investment plan based on expert opinions and publicly available information from pertinent sources. In-depth interviews with experts in manufacturing capacity implementation and regulatory capacity building in Africa complemented the study. The investigation was based on a literature review and supplemented by online questionnaires directed to global vaccine stakeholders, African governments and regulatory authorities. This study aimed to investigate how investment for vaccine production in Africa could be triggered and in which way it could be affordable to most African governments or investors. Conversely, Africa with its high population and economy growth is an increasing potential market for vaccines. ![]() GAVI has significantly helped introduction of new vaccines in Africa but its sustainability is questionable, and new vaccines introduction post-graduation is rare. 4GSK Vaccines Institute for Global Health, Siena, ItalyĪfrica has the highest incidence of mortality caused by infectious diseases, and remarkably does not have the capacity to manufacture vaccines that are essential to reduce mortality, improving life expectancy, and promoting economic growth.3Takeda vaccines, Inc., Chicago, IL, United States.1Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.Geofrey Makenga 1 * †, Stefano Bonoli 2 †, Emanuele Montomoli 1, Trent Carrier 3 † and Joachim Auerbach 4 ![]()
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